A Phenol Glucoside, Uncommon Coumarins and Flavonoids from Pelargonium sidoides DC

Abstract

Structural examination of the metabolic pool of the aerial parts of Pelargonium sidoides DC has led to the isolation of two new metabolites, 4-allyl-2,5-dimethoxyphenol-1-β -D-glucopyranoside and 6,7-dihydroxycoumarin-8-sulfate, along with a series of uncommon compounds including (2R,3R)-(+)-dihydroquercetin-3-β -glucopyranoside, (2R,3R)-(+)-dihydrokaempferol-3-β - glucopyranoside, fraxetin-7-β -glucopyranoside, 7-methoxycoumarin-6-β -glucopyranoside, umckalin, orientin-2”-gallate, and isoorientin-2”-gallate. They are accompanied by the widespread isoorientin, orientin, fraxetin, (2R,3S)-epigallocatechin-3-gallate, gallic acid and protocatechuic acid. The structures of the compounds were established from spectroscopic studies. Determination of configurations was achieved by circular dichroism.