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Sodium exchange and distribution in the isolated heart of the normal dog
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1959
Year
Cardiac MuscleElectrolyte DisorderSodium ExchangeIsolated HeartElectrolyte DisturbanceCardiologyAnimal PhysiologyVeterinary PhysiologySodium HomeostasisTracer TechniqueSmall Animal Internal MedicineIon ChannelsMembrane BiologyPotassium HomeostasisNa 24Normal DogPhysiologyVeterinary ScienceElectrophysiologyCardiovascular PhysiologyMedicineAnesthesiology
Sodium exchange was studied in the isolated normal dog heart with the aid of a Na 24 tracer technique. Transcellular sodium exchange was calculated to be 0.04 mEq/kg/beat. The results are consistent with the concept of sodium influx into the cell during the spike potential, relative membrane impermeability to sodium in the membrane resting state, and a membrane capacity of about 10 µf/cm 2 .