Enhancement of the in-vitro dissolution and in-vivo oral bioavailability of silymarin from liquid-filled hard gelatin capsules of semisolid dispersion using Gelucire 44/14 as a carrier.

Abstract

The solubility and dissolution pattern of silymarin were found to be carrier ratio dependent. Moreover, the in vitro solubility and dissolution data established very good correlation with the calculated in vivo pharmacokinetic parameters. The ratios between the mean AUC(0-12) for GL capsules and that of CP capsules was significantly higher (156.2%). However, the Tmax values of the three formulations remained eventually unchanged.