Time of onset of action of cholera toxin in dog and rabbit.

Abstract

During perfusion of cholera exotoxin through intestinal segments of the rabbit and dog, it was shown that the exotoxin altered the direction of net fluid movement as early as 10 min after its contact with the intestinal mucosa. Gross fluid production did not become obvious until secretion exceeded absorption. Hence, the previously reported delay in the onset of fluid production in response to cholera exotoxin is more apparent than real.