Publication | Open Access
Tumor hypoxia drives immune suppression and immunotherapy resistance
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2015
Year
Cancer ImmunosurveillancePoor OutcomesMedicineImmunologyTumor ImmunityImmunotherapy ResistanceAggressive AdenocarcinomasImmune Checkpoint InhibitorAbstracts Tumor HypoxiaImmunosuppressionCancer TreatmentImmunotherapyOncologyRadiation OncologyTumor MicroenvironmentTumor Biology
Meeting abstracts Tumor hypoxia predicts poor outcomes across all cancers and has long been recognized as a critical source of resistance to both chemotherapy and radiotherapy. Despite the success of T cell immune checkpoint blockade in treating melanoma, aggressive adenocarcinomas of the prostate