Synthesis and biological evaluation of new 2,5-dimethylthiophene/furan based N-acetyl pyrazolines as selective topoisomerase II inhibitors

Abstract

Based on reported pharmacophores as topoisomerase inhibitors, 2,5-dimethylthiophene/furan based<italic>N</italic>-acetyl pyrazolines were designed and envisaged as topoisomerase inhibitors.