Anticancer activity of a cis-dichloridoplatinum(<scp>ii</scp>) complex of a chelating nitrogen mustard: insight into unusual guanine binding mode and low deactivation by glutathione

Abstract

A platinum(<sc>ii</sc>) complex (<bold>2</bold>) of a chelating nitrogen mustard shows potency against MIA PaCa2.<bold>2</bold>displays anti-angiogenic potential and displays excellent cytotoxicity profile even in presence of GSH in hypoxia.