Studies in the sulphur metabolism of the dog

Abstract

THE theory that the organic or ethereal sulphates arise from phenols by conjugation with sulphur compounds other than sulphate, oxiidation occurring subsequently, rests entirely on negative evidence. In more recent years Rhode and Sherwin have supported this theory and Sherwin has gone further, sug- gesting that ethereal sulphates are formed only from sulphur-containing com- plexes of endogenous origin. Rhode [1922] in experiments on rabbits, and Sherwin in collaboration with They made use of phenol itself and of certain halogenated phenols. The chief evidence for the older theory In discussing these differences Pryde [1931] suggests that "guaiacol is a substance too far re- moved from the normal metabolic paths to warrant comparison with phenol in this respect." He makes no comment however on differences in animal species or differences in experimental technique.