NOX2 Activation of Natural Killer T Cells Is Blocked by the Adenosine A _2A Receptor to Inhibit Lung Ischemia–Reperfusion Injury

Abstract

NOX2 plays a key role in inducing iNKT cell-mediated IL-17 production and subsequent lung injury after IR. A primary mechanism for A2AR agonist-mediated protection entails inhibition of NOX2 in iNKT cells. Therefore, agonism of A2ARs on iNKT cells may be a novel therapeutic strategy to prevent primary graft dysfunction after lung transplantation.