International Journal of Pharmacy and Pharmaceutical Sciences · 2016 · 12 citations · 10 references
Open access
PharmacyPharmaceuticsPharmacologyControlled Release FormulationsDrug DeliveryPharmaceutical FormulationDrug FormulationDrug Release From Dosage FormsDrug Release KineticsSustained Release FormulationsTablet DesignTablet FormulationControlled Drug ReleaseControlled Release PolymersFormulation Performance TestingMatrix TabletsOral Drug Delivery FormulationsPolymer Matrix OptimizationRelease Profile CharacterizationUsp Dissolution Apparatus
Objective: An attempt was made to develop sustained release matrix tablets of ibuprofen using HPMC (K4M, K15M & K100M) and eudragit (RS 100 & RL 100) as release retardant polymers. Methods: The ibuprofen matrix tablets were prepared by direct compression method using lactose as a diluent. Nineteen formulations of different polymer percentages were formulated, (F1-F19 with 7.5%, 10%, 15%, 20%, 25%, 30% w/w). Results: The formulations were optimized on the basis of acceptable weight variation, thickness, hardness, % friability, % drug content and in vitro drug release. The in vitro release studies were performed using USP type II apparatus using 7.2 pH phosphate buffer as a dissolution medium, showed that optimized formulation F8 consisting of eudragit RL with 20% of the polymer was found to sustain the release of ibuprofen over a period of 12 h. The formulation exhibited highest correlation (R) value in case of Hixson-Crowell model and the release kinetic study proved that the formulation showed erosion process, and shown to follow zero order kinetics. Conclusion: It was concluded that eudragit RL can be used for the preparation of sustained release tablet of ibuprofen.
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