Pulmonary Imaging Biomarkers of Gas Trapping and Emphysema in COPD:³He MR Imaging and CT Parametric Response Maps

Abstract

In all ex-smokers, ADC values were significantly elevated in regions of PRM gas trapping, and VDP was quantitatively and spatially related to both PRM gas trapping and PRM emphysema. In patients with mild to moderate COPD, VDP was related to PRM gas trapping, whereas in patients with severe COPD, VDP correlated with both PRM gas trapping and PRM emphysema.