Publication | Closed Access
An Approach for the Selective Detection of Nitric Oxide in Biological Systems: An in vitro and in vivo Perspective
27
Citations
34
References
2016
Year
Nitric OxideVivo PerspectiveOptogeneticsOxidative StressNaphthalimide-based Fluorescent ProbeReactive Nitrogen SpecieBioanalysisAnalytical ChemistryNeurologyClinical ChemistryNeurochemistryHealth SciencesBiochemistryNeuropharmacologyNeuroprotectionBiological SystemsPharmacologyRat HippocampusNeurophysiologyPhysiologyNeuroscienceMolecular NeurobiologyChemical ProbeMedicineNitrosative Stress
A naphthalimide-based fluorescent probe, LyNP-NO, was designed and synthesized for the selective detection of exogenously and endogenously generated nitric oxide (NO) in C6 glial cells. In addition, LyNP-NO was also explored for monitoring endogenous NO levels in rat hippocampus at various tissue depths by stimulating the brain with N-methyl-d-aspartate (NMDA).
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