American Journal of Tropical Medicine and Hygiene · 1978 · 29 citations · 0 references
Veterinary MedicineInfectious DiseasesPharmacotherapyAntimicrobial PharmacologyAntimicrobial PharmacotherapyInfectious Disease PharmacotherapyAntiparasitic PharmacologyAntiparasitic PharmacotherapyParasitic DiseasesParasitic InfectionsParasitic PathogenesisRodent Infectious DiseasesToxoplasmosis ChemotherapyToxoplasmosis In RodentsToxoplasmosis PathogenesisToxoplasmosis Treatment
The effectiveness of five treatment regimens was compared to mice during acute and late infection with Toxoplasma gondii. Parasitic cure rates, as judged by failure of brain tissue from surviving mice to produce infection when inoculated into clean mice, were as follows: pyrimethamine + sulfamethoxypyridazine, 92%; clindamycin + sulfamethoxypyridazine, 75%; spiramycin + sulfamethoxypyridazine, 16.7%; trimethoprim + sulfamethoxypryridazine alone, 0%. Pyrimethamine + sulfamethoxypyridazine was the most effective combination against acute toxoplasmosis in mice.