PubMed · 2001 · 27 citations · 0 references
MedicineCardiologyPharmacologyCardiovascular PharmacotherapyNeuropharmacologySubstance Use DisordersAcute Coronary SyndromesCardiac MedicationsDrugs Of AbuseIschemic Heart DiseaseMyocardial Infarction ComplicationsSubstance IntoxicationAcute Myocardial Infarction DiagnosisAmphetamine DerivativesAmphetamine TherapyAmphetamine ToxicityAmphetamine Use DisorderIschemic CardiotoxicityMonoamine PharmacologyMyocardial Infarction Pharmacotherapy
Cardiotoxicity manifesting as myocardial ischemia is not generally recognized as a side effect of amphetamine use or abuse. However, at least 9 cases have been reported since 1987. In this report a case of acute myocardial infarction due to oral amphetamine therapy is presented. The patient was treated with thrombolytic therapy but there were no signs of reperfusion. His coronary cine-angiograms were normal. The literature regarding amphetamine use or abuse is also reviewed, and the possible mechanisms of this pathology are analyzed.