A Specifically Designed Nanoconstruct Associates, Internalizes, Traffics in Cardiovascular Cells, and Accumulates in Failing Myocardium: A New Strategy for Heart Failure Diagnostics and Therapeutics

Abstract

Results show that MSVs associate, internalize, and traffic in cardiovascular cells without any significant toxicity. Furthermore, MSVs accumulate in failing myocardium after intravenous administration, reaching intracellular regions of the cardiomyocytes. These findings represent a novel avenue to develop nanotechnology-based therapeutics and diagnostics in heart failure.