Combinatorial Development of Biomaterials for Clonal Growth of Human Pluripotent Stem Cells - Concepedia

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Combinatorial Development of Biomaterials for Clonal Growth of Human Pluripotent Stem Cells

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2010

Year

Ying Mei, Krishanu Saha, Said R. Bogatyrev, Jing Yang, Andrew L. Hook, Z. Ilke Kalcioglu, Seung‐Woo Cho, Maisam Mitalipova, Neena Pyzocha, Fredrick Rojas,

DSpace@MIT (Massachusetts Institute of Technology)

Tissue EngineeringEngineeringAdult Stem CellBiomaterials DesignSingle CellsBiomedical EngineeringStem Cell MigrationStem Cell BiologyRegenerative MedicineStem CellsStructure–property RelationshipsMaterial MechanicsFunctional Tissue EngineeringCell EngineeringEmbryonic Stem CellsOptimal SubstratesInduced Pluripotent Stem CellDevelopmental BiologyCombinatorial DevelopmentClonal GrowthStem Cell EngineeringStem Cell ResearchStem-cell TherapyMedicineBiomaterialsEmbryonic Stem Cell

Abstract

Structure–property relationships between material properties and stem cell behaviour are investigated using high-throughput methods. The data identify the optimal substrates within a range of different polymeric surfaces to support the growth and self-renewal of human embryonic stem cells from fully dissociated single cells.