Dosimetry in Peptide radionuclide receptor therapy: a review.

TLDR

Targeted therapy with radiolabeled peptides has shown promise in multiple clinical trials, but a general and reliable dosimetric approach for peptide receptor radionuclide therapy remains debated. This article reviews the methods for PRRT dosimetry and the results presented in the literature. The review discusses radiopharmaceutical characteristics, data processing, dosimetric outcomes, organ‑protective methods, and the biological effective dose derived from the linear‑quadratic model.

Abstract

The potential of targeted therapy with radiolabeled peptides has been reported in several clinical trials. Although there have been many improvements in dose estimation, a general and reliable dosimetric approach in peptide receptor radionuclide therapy (PRRT) is still a matter of debate. This article reviews the methods for PRRT dosimetry and the results presented in the literature. Radiopharmaceutical characteristics, data processing, dosimetric outcomes, and methods to protect critical organs are reported. The biological effective dose, based on the linear quadratic model, is also described.