Antidiabetic activity of Thespesia populnea bark and leaf extract against streptozotocin induced diabetic rats.

Abstract

Abstract: Thespesia Populnea is a reputed ever green tree belonging to the family malvaceae; commonly known as Indian tulip tree. The plant is distributed in tropical regions and coastal forest in India. It is well known and all the parts are used in Indian system of medicine. The plant has been used as astringent, antibacterial, hepatoprotective, haemostatic, anti-diarroheal and anti-inflammatory. The ethanolic extract of the plant bark (TPBE) and leaf (TPLE) were evaluated for its effect on blood sugar, against the streptozotocin (STZ)–induced diabetic rats and compared it with standard drug glibenclamide. The result of this experimental study indicates that both the ethanolic extract posses ’ anti-diabetic effect against STZ induced diabetic rats and also showed the possible mechanism due to inhibition of generation of free radical. Key words: Thespesia populnea, Ethanol extract-antidiabetic.