Inhibition of zymosan-induced cytokine and chemokine expression in human corneal fibroblasts by triptolide

Abstract

Triptolide inhibited proinflammatory cytokine and chemokine production by HCFs exposed to zymosan, with this action likely being mediated by suppression of MAPK and NF-κB signaling pathways. This compound might thus be expected to limit the infiltration of inflammatory cells into the cornea associated with fungal infection.