Geografia (Rio Claro) · 2000 · 12 citations · 1 references
Life SciencesInfectious DiseasesMicrobiologyCytoskeletonHost-pathogen InteractionsMicrobial PathogenesisBacterial MotilityBacterial PathogenesisBacterial Secretion SystemsBacterial Virulence FactorsHost-microbe InteractionsMicrobial Virulence FactorsActin-based Cell MotilityActin-based MotilityAmoebic PathogenesisAmoeboid MotilityMacrophage Responses To BacteriaMotility FactorsMycobacterial DiseaseVirulence Determinants
Mycobacterium marinum is a waterborne mycobacterial pathogen. Due to their common niche, protozoa likely represent natural hosts for M. marinum. We demonstrate that the ESX-1 secretion system is required for M. marinum pathogenesis and that M. marinum utilizes actin-based motility in amoebae. Therefore, at least two virulence pathways used by M. marinum in macrophages are conserved during M. marinum infection of amoebae.
1
Pathogenic free-living amoebae in swimming pools: survey in Belgium.
De Jonckheere · PubMed · 1980 · 34 citations