LCZ696, An Angiotensin Receptor–Neprilysin Inhibitor, Improves Cardiac Function with the Attenuation of Fibrosis in Heart Failure with Reduced Ejection Fraction in Streptozotocin-Induced Diabetic Mice

Abstract

The ARNi LCZ696 improved cardiac function with the reduction of fibrosis in an HF-rEF model in diabetic mice, by suppressing TGF-β. This effect may be due to the specific inhibition of neprilysin, beyond the ARB effect of LCZ696.