Publication | Closed Access
Application of seady-state kinetics to studies of the transfer of 5-hydroxyindoleacetic acid from brain to plasma.
306
Citations
0
References
1967
Year
NeurotransmitterSocial SciencesCerebral Vascular RegulationCerebrospinal FluidNeurochemistryNeuropharmacologyNervous SystemSeady-state KineticsPharmacologyCerebral Blood FlowDopamineBrain MetabolismRenal Tubular Secretion5-Hydroxyindoleacetic AcidNeurophysiologyPhysiologyProbenecid AdministrationElectrophysiologyNeuroscienceCentral Nervous SystemBrain ElectrophysiologyMedicine
Probenecid, a drug that competitively inhibits the renal tubular secretion of a number of acidic substances, also blocks the efflux of 5-hy-droxyindoleacetic acid (5-HIAA) from rat brain. The rate at which 5-HIAA is accumulated after probenecid administration almost exactly equals the rate of formation of this acid from serotonin (5-HT). These results imply that 5-HIAA and perhaps other acidic products of brain metabolism are transferred directly from brain to plasma by a specialized process.