Prevention of hypoxic pulmonary hypertension by chlorpheniramine.

Abstract

hypoxic pulmonary hypertension bv chlorpheniramine. J. Appl. Physiol. jl(4) : 531-535. 197 1.-Recent studies conducted in isolated Twenty-eight mongrel dogs of both sexes (weight range lungs suggest that histamine mediates hypoxic pulmonary hyper- 12.3-23.5 kg; mean 16.2 kg) were anesthetized with a mix-tension. Twenty-eight anesthetized dogs experienced an average ture (Innovar-Vet, McNeil Laboratories, Fort Washington, increase in mean pulmonary arterial pressure of 3.5 mm Hg, with pheniramine did not modify pulmonary vascular resistance in the a corresponding increase in pulmonary vascular resistance, while breathing an 8a/o oxygen inspired gas mixture. Neither diphen-hydramine nor promethazine uniform1 y abolished the pulmonary absence of hypoxia. This and the lack of inhibition of pulmonary pressor response to hypoxia. Chlorpheniramine reversed the pul-hypertension induced by serotonin further suggest that the anti-monary hypertension with an average fall in mean pulmonary histaminic property of chlorpheniramine is responsible for its arterial pressure of 3.9 mm Hg and in pulmonary arteriolar re-