PubMed · 1979 · 73 citations · 2 references
PharmacyPharmacologyPharmacotherapyAntimicrobial PharmacotherapyClinical PharmacologyInfectious Disease PharmacotherapyAntiparasitic ChemotherapyAntiparasitic PharmacologyAntiparasitic PharmacotherapyAntiparasitic TherapyCombination Antimicrobial TherapyMalariaAntimalarial AgentsAntimalarial Drug CombinationsChemotherapy Of MalariaMalaria ChemoprophylaxisPlasmodium FalciparumSingle-dose AdministrationSingle-dose TherapyTreatment Of Malaria
A single oral dose (1.5 g) of mefloquine hydrochloride cured all of 37 patients with falciparum malaria, and a single dose of pyrimethamine (75 mg) plus sulfadoxine (1.5 g) cured 34 of 38 patients. The rates at which parasitaemia and fever abated were similar for the two regimens but mefloquine was associated with a higher incidence of gastrointestinal side effects.
2
Mefloquine (WR 142,490) in the Treatment of Human Malaria
Gordon M. Trenholme, Roger Williams, Robert E. Desjardins et al. · Science · 1975 · 176 citations