Angewandte Chemie International Edition · 2000 · 203 citations · 0 references
Natural SciencesBiophysicsChemistryBiophotonicsBiophysical ChemistryMolecular ImagingChemical Probe DiscoveryFluorescence ImagingFluorescence SpectroscopyNanomedicinePhotophysics Of Fluorescent ProbesFluorescence ProbesFluorescent Chemical ProbesFluorescent DyesFluorescent Probe DesignFluorescent ProbesFluorophore ChemistryFluorophore DesignPh Dependence
Fluorophore plus a macrocyclic polyamine blend into a probe for zinc that is active under physiological conditions. Compound 1 (X=Cl) increased fluorescence intensity 26-fold upon addition of ZnII, yet is insensitive to other common metals. The probes are active at a range of pH values, most importantly at pH 7. These probes do not need biologically harmful UV irradiation for fluoroescent activity.