Proximal effect of the nitrogen ligands in the catalytic epoxidation of olefins by the sodium hypochlorite/manganese(III) porphyrin system

Abstract

Using synthetic manganese porphyrin complexes with an imidazole or a pyridine ligand covalently attached to the macrocycle, we report the control of the reaction rate, product selectivity, and stereoselectivity by the axial ligand trans to the active site of the catalyst. The results clearly illustrate the proximal effect on nitrogen ligands in this cytochrome P-450 model. © 1988, American Chemical Society. All rights reserved.