THE SYNDROME OF HYPOPARATHYROIDISM, ADDISION'S DISEASE AND MONILIASIS

Abstract

Summary An eighth example of the rare combination of idiopathic hypoparathyroidism and Addison's disease is reported. A girl, aged 16 years, had suffered epileptic fits since the age of 10. Investigations showed cerebral calcification, with low serum calcium, raised inorganic phosphorus and normal blood urea nitrogen content. She also showed typical clinical and biochemical features of Addison's disease. Treatment with cortisone and large doses of A.T.10 led to improvement in her clinical state and also in her I.Q., electroencephalogram and electrocardiogram. The, initial administration of cortisone led to a fall in serum calcium content, and, subsequently, control of the Addison's disease necessitated larger than usual doses of A.T. 10. The clinical course of this and other previously reported cases provides some evidence of an antagonism between the parathyroid and adrenal glands.