Mapping the resistance-associated mobilome of a carbapenem-resistant<i>Klebsiella pneumoniae</i>strain reveals insights into factors shaping these regions and facilitates generation of a ‘resistance-disarmed’ model organism

Abstract

This study has reiterated the role of plasmids as bearers of the vast majority of resistance genes in this species and has provided valuable insights into the vital role played by ISs, transposons and integrons in shaping the resistance-coding regions in this important strain. The 'resistance-disarmed' K. pneumoniae ST11 strain generated in this study will offer a more benign and readily genetically modifiable model organism for future extensive functional studies.