The role of polymorphonuclear leucocytes in protecting mice vaccinated against Pseudomon as aeruginosa infections.

Abstract

In the presence of serum from normal unvaccinated mice polymorphonuclear leucocytes taken from mice 1, 2, 3 and 4 days after one injection of a pseudomonas vaccine phagocytosed progressively more bacteria on each successive day. More bacteria were phagocytosed by polymorphs from vaccinated mice in serum taken 3, 4 or 7 days after vaccination than in serum taken earlier. Polymorphs from vaccinated mice ingested more of the strains of bacteria against which vaccinated mice were protected than other pseudomonas strains.