Tigecycline resistance in clinical isolates of<i>Enterococcus faecium</i>is mediated by an upregulation of plasmid-encoded tetracycline determinants<i>tet</i>(L) and<i>tet</i>(M)

Abstract

Our results indicate that increased expression of two tetracycline resistance determinants, a tet(L)-encoded MFS pump and a tet(M)-encoded ribosomal protection protein, is capable of conferring tigecycline resistance in enterococcal clinical isolates.