YAKUGAKU ZASSHI · 1988 · 49 citations · 0 references
MedicineMedicinal ChemistryPharmacologyBiochemical PharmacologyHemostasisStructure-activity RelationshipsEnzyme InhibitionPlatelet ActivationPlatelet AggregationPlatelet FunctionPlatelet PhysiologyActive PrincipleAdenosine Diphosphate-induced Platelet AggregationArachidonic Acid SignalingColumn ChromatographyGlycoside Natural ProductsPlatelet Aggregation InhibitionPlatelet InhibitionPolysaccharide Natural Products
In the course of screening of natural products for platelet aggregation inhibitor in rabbit and human platelet, the extracts of Anemarrhenae Rhizoma was found to inhibit adenosine diphosphate (ADP)-induced platelet aggregation. The active components were isolated by column chromatography monitoring inhibitory activity of platelet aggregation and identified as tiomosaponin A-III and markogenin-3-O-β-D-glucopyranosyl-(1→2)-β-D-galactopyranoside by means of spectroscopic analysis. Timosaponin A-III and markogenin glycoside were found to inhibit ADP-induced aggregation as well as 5-HT or arachidonic acid-induced aggregation of human platelet.