Immunohistochemical evaluation of CXCL12-CXCR4 axis and VEGFR3 expression in primary urothelial cancer and its recurrence. - Concepedia

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Immunohistochemical evaluation of CXCL12-CXCR4 axis and VEGFR3 expression in primary urothelial cancer and its recurrence.

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2014

Year

Ourania Batsi, Ioanna Giannopoulou, Ioannis Nesseris, Christos Valavanis, Hariklia Gakiopoulou, Efstratios Patsouris, Petroula Arapandoni-Dadioti, Andreas C. Lazaris

Abstract

CXCL12 and CXCR4 expression was related to adverse prognostic markers in urothelial bladder carcinoma through their association with grade and pT stage both in PC and RC. The CXCL12-CXCR4 axis may influence the expression of VEGFR3 in urothelial bladder carcinoma and promote tumor recurrence.