Factors involved in the effects of losartan on endothelialdysfunction induced by aging in SHR

Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.

Sanjay Rajagopalan, Stephan Kurz, Thomas Münzel et al. · Journal of Clinical Investigation · 1996 · 2.4K citations · Full text

Life Sciences, Pharmacology, Physiology +16

Endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat.

Thomas F. Lüscher, Paul M. Vanhoutte · Hypertension · 1986 · 879 citations · Full text

Life Sciences, Pharmacology, Physiology +15

Indirect evidence for release of endothelium-derived relaxing factor in human forearm circulation in vivo. Blunted response in essential hypertension.

Lilly Linder, Wolfgang Kiowski, Fritz R. Bühler et al. · Circulation · 1990 · 801 citations · Full text

Medicine, Pharmacology, Physiology +11

Role of endothelium-derived nitric oxide in the abnormal endothelium-dependent vascular relaxation of patients with essential hypertension.

Julio A. Panza, Philip R. Casino, Crescence M. Kilcoyne et al. · Circulation · 1993 · 709 citations · Full text

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Vasodilation to acetylcholine in primary and secondary forms of human hypertension.

Stefano Taddei, Agostino Virdis, Paola Mattei et al. · Hypertension · 1993 · 536 citations · Full text

Medicine, Cardiology, Physiology +16