Concepedia

Metformin as a prevention and treatment for preeclampsia: effects on soluble fms-like tyrosine kinase 1 and soluble endoglin secretion and endothelial dysfunction

Fiona Brownfoot, Roxanne Hastie, Natalie J. Hannan, Ping Cannon, Laura Tuohey, Laura J. Parry, Sevvandi Senadheera, Sebastián E. Illanes, Tu’uhevaha J. Kaitu’u‐Lino, Stephen Tong

American Journal of Obstetrics and Gynecology · 2015 · 220 citations · 67 references

Concepts

MedicineObstetricsPharmacologyHigh-risk PregnancyMaternal-fetal MedicineReproductive EndocrinologyEclampsiaEndothelial DysfunctionHypertensive DisordersPregnancy EndocrinologyPregnancy-induced HypertensionEndoglin SignalingHypertensive Disorder PreventionManagement Of Pre-eclampsiaPlacental Dysfunction In PreeclampsiaPreeclampsia PathophysiologyPreeclampsia Risk ReductionVascular Endothelial Dysfunction

References

67

Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia

Sharon E. Maynard, Jiang-Yong Min, Jaime R. Merchan et al. · Journal of Clinical Investigation · 2003 · 4K citations · Full text

Medicine, Maternal Health, Obstetrics +17

Hypertension in Pregnancy

Obstetrics and Gynecology · 2013 · 3.9K citations

Medicine, Gynecology, Obstetrics +9

Circulating Angiogenic Factors and the Risk of Preeclampsia

Richard J. Levine, Cong Qian, Lucinda J. England et al. · New England Journal of Medicine · 2004 · 3.6K citations · Full text

Public Health, Maternal Health, Obstetrics +11

Circulating angiogenic factors and the risk of preeclampsia*

Obstetrics and Gynecology · 2004 · 2.6K citations

Medicine, Gynecology, Obstetrics +14

Preeclampsia: An endothelial cell disorder

James Roberts, Robert N. Taylor, Thomas J. Musci et al. · American Journal of Obstetrics and Gynecology · 1989 · 1.9K citations

Medicine, Gynecology, Obstetrics +11