Loss of <i>TBK1</i> is a frequent cause of frontotemporal dementia in a Belgian cohort

Abstract

TBK1 LOF mutations are the third most frequent cause of clinical FTD in the Belgian clinically based patient cohort, after C9orf72 and GRN, and the second most common cause of clinical ALS after C9orf72. These findings reinforce that FTD and ALS belong to the same disease continuum.