Expression of HLA-DR is reduced in tumor infiltrating immune cells (TIICs) and regional lymph nodes of non-small-cell lung carcinomas. A putative mechanism of tumor-induced immunosuppression? - Concepedia

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Expression of HLA-DR is reduced in tumor infiltrating immune cells (TIICs) and regional lymph nodes of non-small-cell lung carcinomas. A putative mechanism of tumor-induced immunosuppression?

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References

2001

Year

Periklis Foukas, Vassilis Tsilivakos, P Zacharatos, G. Mariatos, Sterghios Moschos, A Syrianou, Panayiotis J. Asimacopoulos, J Bramis, C Fotiadis, C Kittas,

Abstract

The impairment of HLA-DR expression, detected both in neoplastic and by-stander immune cells, may justify the immunosuppression observed in NSCLC. This phenomenon may be due to a putative soluble factor in the tumor environment secreted by cancer cells.