Hypoxia-Inducible Factor-1α Gene Expression and Apoptosis in Ischemia–Reperfusion Injury

Abstract

These results suggest that mitochondria-mediated apoptotic pathways may be involved in the development of early-stage PU, and HIF-1α might play a potential role for promoting apoptosis. Inflammation, oxidative stress reaction, and energy depletion may cooperate in the process of I/R injury of early-stage PU.