Transmission of the M Strain of Plasmodium cynomolgi to Man

Abstract

SummaryAttempts to transmit the classical M strain of Plasmodium cynomolgi to man via mosquito resulted in a low-grade infection in only one (a Caucasian) of eleven volunteers, two Negroes and nine whites.Subsequent passage of this strain through human volunteers increased its capacity to produce infections and clinical manifestations.Residence in the human subject did not alter the capacity of the strain to produce characteristic M-type infections in the rhesus monkey.