Synthesis, spectral and antimicrobial studies of chlorodiorganotin(IV)[3(2′-hydroxyphenyl)-5-(4-substitutedphenyl) pyrazolinates]

Abstract

Chlorodiorganotin(IV)pyrazolinates of the type R2SnCl(C15H12N2O · X) [where C15H12N2O · X = 3(2′-Hydroxyphenyl)-5(4-X-phenyl)pyrazoline {where X = H (a); CH3 (b); OCH3 (c); Cl (d) and R = Me, Pr n and Ph}] have been synthesized by reaction of R2SnCl2 with the sodium salt of pyrazolines in 1 : 1 molar ratio, in anhydrous benzene. These newly synthesized derivatives have been characterized by elemental analysis (C, H, N, Cl and Sn), molecular weight measurement and spectral studies [IR and multinuclear NMR (1H, 13C and 119Sn)]. The bidentate behavior of the ligands was confirmed by IR, 1H and 13C NMR spectral data. Trigonal bipyramidal structure around tin(IV) for R2SnCl(C15H12N2O · X) is suggested. The free pyrazoline and some chlorodiorganotin(IV) pyrazolinates have been screened for their antibacterial and antifungal activities. Some chlorodiorganotin(IV) pyrazolinates exhibit higher antibacterial and antifungal effect than free pyrazoline and some antibiotics.