Rapid oral desensitization for sulfonamides in patients with the acquired immunodeficiency syndrome.

Abstract

Overall, 11 of 13 (85%) patients were successfully desensitized to sulfonamides using both rapid and slow methods. No life-threatening reactions occurred. Premedications with oral antihistamines and corticosteroids may be needed to control and prevent early occurrences of rash or pruritus during desensitization. In those who fail rapid desensitization, the slow method with premedications is an alternative.