Concepedia

A small molecule probe reveals declined mitochondrial thioredoxin reductase activity in a Parkinson's disease model

Yaping Liu, Huilong Ma, Liangwei Zhang, Yajing Cui, Xiaoting Liu, Jianguo Fang

Chemical Communications · 2015 · 73 citations · 25 references

DOI

Concepts

Abstract

The first off-on probe, Mito-TRFS, for imaging the mitochondrial thioredoxin reductase (TrxR2) in live cells was reported. In a cellular model of Parkinson's disease (PD), Mito-TRFS staining discloses a drastic decline of the TrxR2 activity, providing a mechanistic link of TrxR2 dysfunction to the etiology of PD.

References

25

Development of Targetable Two-Photon Fluorescent Probes to Image Hypochlorous Acid in Mitochondria and Lysosome in Live Cell and Inflamed Mouse Model

Lin Yuan, Lu Wang, Bikram Keshari Agrawalla et al. · Journal of the American Chemical Society · 2015 · 556 citations

, , +17

Mitochondria-Immobilized pH-Sensitive Off–On Fluorescent Probe

Min Hee Lee, Nayoung Park, Chunsik Yi et al. · Journal of the American Chemical Society · 2014 · 465 citations · Full text

, , +17

Mitochondria‐Targeted Cancer Therapy Using a Light‐Up Probe with Aggregation‐Induced‐Emission Characteristics

Qinglian Hu, Meng Gao, Guangxue Feng et al. · Angewandte Chemie International Edition · 2014 · 415 citations

, , +16

Selenoprotein oxidoreductase with specificity for thioredoxin and glutathione systems

Qi-An Sun, Leo Kirnarsky, Simon Sherman et al. · Proceedings of the National Academy of Sciences · 2001 · 315 citations · Full text

, , +17

Highly Selective Off–On Fluorescent Probe for Imaging Thioredoxin Reductase in Living Cells

Liangwei Zhang, Dongzhu Duan, Yaping Liu et al. · Journal of the American Chemical Society · 2013 · 261 citations · Full text

, , +17