Regioselective Copper‐Catalyzed Oxidative Cross‐Coupling of Imidazo[1,2‐<i>a</i>]pyridines with Methyl Ketones: An Efficient Route for Synthesis of 1,2‐Diketones

Abstract

Abstract An efficient copper‐catalyzed oxidative coupling of imidazo[1,2‐ a ]pyridines with methyl ketones to directly generate structurally sophisticated 1,2‐dicarbonyl imidazo[1,2‐ a ]pyridine derivatives under oxidative conditions is described. The reaction proceeds in good yields using the environmental friendly molecular oxygen as the oxidant. 18 O‐Labelling experiments unambiguously established that the oxygen of the dicarbonyl products originated from oxygen rather than from water. magnified image