Pitx2c increases in atrial myocytes from chronic atrial fibrillation patients enhancing<i>I</i>_Ksand decreasing<i>I</i>_Ca,L

Abstract

Our results demonstrated for the first time that CAF increases Pitx2c expression in isolated human atrial myocytes and suggested that this transcription factor could contribute to the CAF-induced IKs increase and ICa,L reduction observed in humans.