Single Nucleotide Polymorphisms in<i>P2X7</i>Gene Are Associated with Serum Immunoglobulin G Responses to<i>Mycobacterium tuberculosis</i>in Tuberculosis Patients

Abstract

P2X7 SNPs, 1513A>C and -762T>C, may be associated with the susceptibility to tuberculosis, and -762T>C SNP may contribute to the development of MTB. The mutant genotype of -762T>C (TC and CC) may lower human capability of phagocytosis to MTB, leading to an increased morbidity of TB.