Phosphoinositides. 3. Enzymic hydrolysis of inositol-containing phospholipids

Abstract

Sloane-Stanley (1953) and Rodnight (1956) described the hydrolysis of ox-brain 'diphospho- inositide' preparations (Folch, 1949) by extracts of brain and other tissues. Dawson (1954) and Hokin & Hokin (1956) showed that the phosphoinositide fraction of several tissues had a high tumover rate, as measured by the incorporation of 82P. The exact structure of the phosphoinositides involved is not known in every case, but it seems that the phosphate of phosphatidylinositol has a rapid tumover in several tissues (see Hawthorne, 1960a).