R-Duloxetine and N-Methyl Duloxetine as Novel Analgesics Against Experimental Postincisional Pain

Abstract

R-Duloxetine and N-methyl duloxetine are highly effective against postoperative pain using the skin incision model, and they elicit both tonic and use-dependent block of neuronal Na⁺ channels. Our results suggest that R-duloxetine and N-methyl duloxetine are applicable as novel analgesics.