Clinical and Experimental Hypertension Part A Theory and Practice · 1984 · 12 citations · 18 references
MedicinePharmacologyPhysiologyCardiovascular PharmacotherapyNeuropharmacologyPharmacodynamicsBlood Pressure RegulationCardiovascular PharmacodynamicsHemodynamic PharmacologyHemodynamicsHypertension PharmacotherapyRenal HemodynamicsAntihypertensive PharmacologyArterial Blood Pressure MeasurementBlood FlowCardiac IndexHeart RateHemodynamic Drug EffectsRenal Hemodynamic EffectsTotal Resistance
To determine the effects of the recently synthesized slow channel calcium blocker nitrendipine on systemic and regional hemodynamics, mean arterial pressure, heart rate, cardiac index and organ blood flow distribution were measured with the combined radioactive reference sample and microsphere techniques before and one hour after its oral administration (1 mg or 10 mg/kg). Twenty-week-old normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) conscious male rats were studied. At the 10 mg dose, nitrendipine exerted a hypotensive effect within 15 minutes, and this effect persisted throughout the study. After one hour, mean arterial pressure fell by 14 percent of pretreatment levels in WKY controls; it fell by 25 percent in SHR (p less than 0.001). This action was mediated by a fall in total peripheral resistance index (p less than 0.01) that was nonuniformly distributed to the organ circulations since blood flow was maintained or increased to brain, heart, kidneys, lungs, and adrenals, but decreased to skin. No change in cardiac index was observed.
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Treatment of hypertension with nifedipine, a calcium antagonistic agent.
M. T. Olivari, C Bartorelli, A Polese et al. · Circulation · 1979 · 358 citations · Full text