Efficacy of vancomycin extended-dosing regimens for treatment of simulated<i>Clostridium difficile</i>infection within an<i>in vitro</i>human gut model

Abstract

The two vancomycin extended-dosing regimens were efficacious in initial treatment of simulated CDI. Both had a prolonged deleterious effect on the indigenous gut microbiota, a factor that may contribute to recurrence; recurrence was observed only in Model B, although the potential for vegetative regrowth within Model A cannot be excluded. Vancomycin exposure appeared to select for VTE populations.