Concepedia

Publication | Open Access

Caffeine protects against experimental acute pancreatitis by inhibition of inositol 1,4,5-trisphosphate receptor-mediated Ca <sup>2+</sup> release

DOIFull Paper Access

101

Citations

45

References

2015

Year

Wei Huang, Matthew C. Cane, Rajarshi Mukherjee, Peter Szatmary, Xiaoying Zhang, Victoria A. Elliott, Yulin Ouyang, Michael Chvanov, Diane Latawiec, Li Wen,
Gut

Abstract

Caffeine and its dimethylxanthine metabolites reduced pathological IP<sub>3</sub>R-mediated pancreatic acinar Ca<sup>2+</sup> signals but only caffeine ameliorated experimental AP. Caffeine is a suitable starting point for medicinal chemistry.

References

YearCitations

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