The Concise Guide to PHARMACOLOGY 2015/16: Enzymes

TLDR

The Concise Guide to PHARMACOLOGY 2015/16 offers concise overviews of over 1750 human drug targets, including the eight major pharmacological classes such as GPCRs, with links to an open‑access knowledgebase for detailed target and ligand information. The guide aims to supply the official IUPHAR classification and nomenclature for human drug targets and to consolidate previously curated data into a permanent, citable record that persists beyond database updates. It presents each target with nomenclature guidance, summary pharmacological tools, key references, and suggestions for further reading. Full contents are available at http://onlinelibrary.wiley.com/doi/10.1111/bph.13354/full.

Abstract

The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands ( www.guidetopharmacology.org ), which provides more detailed views of target and ligand properties. The full contents can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.13354/full . G protein‐coupled receptors are one of the eight major pharmacological targets into which the Guide is divided, with the others being: G protein‐coupled receptors, ligand‐gated ion channels, voltage‐gated ion channels, other ion channels, nuclear hormone receptors, catalytic receptors and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The Concise Guide is published in landscape format in order to facilitate comparison of related targets. It is a condensed version of material contemporary to late 2015, which is presented in greater detail and constantly updated on the website www.guidetopharmacology.org , superseding data presented in the previous Guides to Receptors & Channels and the Concise Guide to PHARMACOLOGY 2013/14. It is produced in conjunction with NC‐IUPHAR and provides the official IUPHAR classification and nomenclature for human drug targets, where appropriate. It consolidates information previously curated and displayed separately in IUPHAR‐DB and GRAC and provides a permanent, citable, point‐in‐time record that will survive database updates.